Severe brain injuries—whether from trauma, bleeding, or blocked vessels—are among the most devastating medical emergencies worldwide. But it’s not just the initial impact that puts the brain at risk. The real danger often comes in the hours that follow.After the primary injury, the brain enters a fragile state, vulnerable to secondary damage caused by swelling, inflammation, and especially fever. These responses can rapidly escalate, turning treatable injuries into life-altering or fatal outcomes.In neurocritical care, timing is everything. The faster and more precisely we protect the brain, the greater the chance of survival—and recovery. That’s exactly where TEQCool is poised to make a difference.
Fever is one of the most damaging—and overlooked—threats to the injured brain. It affects up to 70% of acute brain injury patients, and it’s often caused by the injury itself, not infection. Even a 1°C rise in temperature can worsen brain swelling, disrupt metabolism, and increase the risk of poor outcomes. In fact, research consistently shows that reducing fever improves brain recovery, while uncontrolled fever is linked to higher mortality and worse neurological function.
Prevention and/or treatment of fever is implemented and considered standard care in the clinical management of acute brain injury patients. The use of temperature management aiming at hypothermia has been included in several care guidelines in patients with traumatic brain injury, subarachnoid hemorrhage, stroke, Neonatal Ischemic Encephalopathy.
Whether through normothermia (fever prevention) or therapeutic hypothermia (cooling), temperature management is not optional—it’s essential.
Our goal is to meet this standard—and go beyond it. With rapid, targeted brain cooling through a non-invasive method, our technology offers a smarter, safer, and more effective way to fight one of the brain’s biggest threats: time.
References:
1 Covaciu L et al. (2011) Brain temperature in volunteers subjected to intranasal cooling. Intensive Care Med 37(8):1277-84.
2 Badjatia N (2009) Hyperthermia and fever control in brain injury. Crit Care Med 37:250-257
3 Li J, Jiang J-Y (2012) Chinese Head Trauma Data Bank: Effect of Hyperthermia on the Outcome of Acute Head Trauma Patients. J Neurotrauma 29:96-100
4 Dietrich WD, Bramlett H (2010) The evidence for hypothermia as a neuroprotectant in traumatic brain injury. Neurotherapeutics 7:43-50
5 Pegoli M, Zurlo Z, Bilotta F (2020) Temperature management in acute brain injury: A systematic review of clinical evidence. Clin Neurol Neurosurg 197:106165
6 Madden LK, Hill M et al (2017) The implementation of targeted temperature management: an evidence-based guideline from the neurocritical care society. Neurocrit Care 27:468-487
7 Cariou A, Payen J-F et al (2018) Targeted temperature management in the ICU: Guidelines from a French expert panel. Anaesth Crit Care Pain Med 37:481-491
8 Diringer M, Bleck T et al (2011) Critical care management of patients following aneurysmal subarachnoidal hemorrhage: recommendations from the Neurocritical Care Society´s Multidisciplinary Consensus Conference. Neurocrit Care 15:211-240
9 Powers WJ, Rabenstein AA et al (2019) Guidelines for the early management of patients with acute ischemic stroke: 2019 update to the 2018 guidelines: A guideline for Healthcare professionals from the American Heart Association/American Stroke Association. Stroke 50(12):e344-e418.
10 Lavinio A, Andrzejowski J et al (2023) Targeted temperature management in patients with intracerebral haemorrhage, subarachnoidal haemorrhage, or acute ischaemic stroke: updated consensus guideline recommendations by the Neuroprotective Therapy Consensus Review (NTCR) group. Br J Anaesth 131(2):294-301.